Papers for discussion


Clarkson JE, Pitts NB, Goulao B, et al. (2020) Trial Design and Methods. NIHR Journals Library.

Lira-Oetiker M, Seguel-Galdames F, Quero-Vallejos I, et al. (2018) Randomised clinical trial of patient satisfaction with traditional and simplified complete dentures. Journal of oral rehabilitation 45(5): 386–392.

Appel LJ, Moore TJ, Obarzanek E, et al. (1997) A clinical trial of the effects of dietary patterns on blood pressure. The New England journal of medicine 336(16). 10 Shattuck, Boston, Ma 02115: Mass Medical Soc: 1117–1124.

Howell TH, Fiorellini JP, Paquette DW, et al. (1997) A phase I/II clinical trial to evaluate a combination of recombinant human platelet-derived growth factor-BB and recombinant human insulin-like growth factor-I in patients with periodontal disease. Journal of periodontology 68(12): 1186–1193.

Tonetti MS, Lang NP, Cortellini P, et al. (2002) Enamel matrix proteins in the regenerative therapy of deep intrabony defects. Journal of clinical periodontology 29(4): 317–325.

Innes NP, Clarkson JE, Speed C, et al. (2013) The FiCTION dental trial protocol -- filling children’s teeth: indicated or not? BMC oral health 13(1): 25.

Maguire A, Clarkson JE, Douglas GV, et al. (2020) Best-practice prevention alone or with conventional or biological caries management for 3- to 7-year-olds: the FiCTION three-arm RCT. Health technology assessment 24(1): 1–174.

Elhennawy K, Finke C, Paris S, et al. (2021) Selective vs stepwise removal of deep carious lesions in primary molars: 24 months follow-up from a randomized controlled trial. Clinical oral investigations 25(2): 645–652.

Basili CP, Emilson CG, Corvalan GC, et al. (2017) Preventive and Therapeutic Proximal Sealing: A 3.5-Year Randomized Controlled Clinical Trial Follow-Up. Caries research 51(4): 387–393.


Jayaraman J, Dhar V, Donly KJ, et al. (2019) Reporting stAndards for research in PedIatric Dentistry (RAPID): a development protocol. International journal of paediatric dentistry / the British Paedodontic Society [and] the International Association of Dentistry for Children. DOI: 10.1111/ipd.12569.

Lamont T, Schwendicke F and Innes N (2015) Why we need a core outcome set for trials of interventions for prevention and management of caries. Evidence-based dentistry 16(3): 66–68.

Kalenderian E, Tokede B, Ramoni R, et al. (2015) Dental clinical research: an illustration of the value of standardized diagnostic terms. Journal of public health dentistry. DOI: 10.1111/jphd.12124.

Sung Y-H, Kim H-Y, Son H-H, et al. (2014) How to design in situ studies: an evaluation of experimental protocols. Restorative dentistry & endodontics 39(3): 164–171.

Pocock SJ, Travison TG and Wruck LM (2007) Figures in clinical trial reports: current practice & scope for improvement. Trials 8: 36.

Zanatta RF, Silva TM da, Esper MALR, et al. (2017) Guidelines for conducting split-mouth clinical studies in restorative dentistry. Brazilian Dental Science 20(2): 29.

Innes NPT, Schwendicke F and Lamont T (2016) How do we create, and improve, the evidence base? British dental journal 220(12): 651–655.

Groves T (2010) What makes a high quality clinical research paper? Oral diseases 16(4): 313–315.

Lesaffre E, Garcia Zattera M-J, Redmond C, et al. (2007) Reported methodological quality of split-mouth studies. Journal of clinical periodontology 34(9): 756–761.

Hickel R, Roulet JF, Bayne S, et al. (2007) Recommendations for conducting controlled clinical studies of dental restorative materials. International dental journal 57(5): 300–302.

Jadad AR, Moore RA, Carroll D, et al. (1996) Assessing the quality of reports of randomized clinical trials: is blinding necessary? Controlled clinical trials 17(1): 1–12.

Peumans M, Kanumilli P, Demunck J, et al. (09/2005) Clinical effectiveness of contemporary adhesives: A systematic review of current clinical trials. Dental materials: official publication of the Academy of Dental Materials 21(9): 864–881.

Gunsolley J (1998) Equivalence, superiority, and negative clinical trials. Journal of periodontology.

Gunsolley JC, Elswick RK and Davenport JM (1998) Equivalence and superiority testing in regeneration clinical trials. Journal of periodontology 69(5): 521–527.

Pandis N, Fleming PS, Katsaros C, et al. (2021) Dental Research Waste in Design, Analysis, and Reporting: A Scoping Review. Journal of dental research 100(3): 245–252.

Pandis N, Fleming PS, Katsaros C, et al. (2021) Dental Research Waste in Design, Analysis, and Reporting: A Scoping Review. Journal of dental research 100(3): 245–252.

Common Statistical Myths

Ioannidis JPA, Cripps S and Tanner MA (2020) Forecasting for COVID-19 has failed. International journal of forecasting. DOI: 10.1016/j.ijforecast.2020.08.004.


Wilkinson J, Arnold KF, Murray EJ, et al. (2020) Time to reality check the promises of machine learning-powered precision medicine. The Lancet Digital Health. Elsevier. DOI: 10.1016/S2589-7500(20)30200-4.

Ioannidis J (2005) Why Most Published Research Findings Are False. PLoS medicine 2(8). DOI: 10.1371/journal.pmed.0020124.


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